We have asked big names from the world of boxing for their opinions on the big fight.
Middleweight Liam Smith: "I'm going to edge towards Crawford but I wouldn't be surprised with any result. They are two elite fighters at the top of their game."
Two-weight world champion Natasha Jonas: "I change my mind with Spence-Crawford all the time. But right now, it's Spence."
Retired heavyweight Mike Tyson: "It's close. I think Crawford will win, if he wins easy I will be totally surprised."
Former featherweight world champion Kid Galahad: "I'm going with Spence - look at the face of opponents after they've fought Spence versus the other welterweight champs."
5 Live boxing analyst Steve Bunce: "I think it might come down to who's the smartest. Some people are convinced that's Spence but I think Crawford might be smarter. The main unknown about this fight is who's got the most left in the tank. I've just got a feeling it might be Crawford. But even though I'm favouring Crawford, I would be stunned if one of them walks away with this fight. I'd be absolutely amazed if there's one master."
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